Drug interactions
Oxcarbazepine + Pimozide
Severity: Moderate
Oxcarbazepine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak CYP3A4 inducer and may reduce pimozide concentrations, with possible loss of efficacy. Pimozide may lower the seizure threshold, opposing oxcarbazepine's anticonvulsant effect.
What this interaction means in plain words
Oxcarbazepine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by oxcarbazepine increases pimozide clearance.
What to do
Monitor clinical response and seizure control, and adjust pimozide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Pimozide?
MediHelp rates the interaction as moderate. Oxcarbazepine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak CYP3A4 inducer and may reduce pimozide concentrations, with possible loss of efficacy. Pimozide may lower the seizure threshold, opposing oxcarbazepine's anticonvulsant effect.
How serious is the interaction between Oxcarbazepine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and seizure control, and adjust pimozide dose as needed.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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