Drug interactions
Oxcarbazepine + Sofosbuvir / velpatasvir
Severity: Major
Oxcarbazepine and Sofosbuvir / velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir and sofosbuvir exposure can fall with inducers of CYP3A4, CYP2C8, CYP2B6 and P-gp. Lower levels may cause hepatitis C treatment failure. Labeling advises against use with oxcarbazepine.
What this interaction means in plain words
Oxcarbazepine and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Oxcarbazepine induces CYP enzymes and P-glycoprotein, reducing velpatasvir and sofosbuvir concentrations.
What to do
Avoid the combination and switch to a non-inducing anticonvulsant such as levetiracetam before starting therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Oxcarbazepine and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir and sofosbuvir exposure can fall with inducers of CYP3A4, CYP2C8, CYP2B6 and P-gp. Lower levels may cause hepatitis C treatment failure. Labeling advises against use with oxcarbazepine.
How serious is the interaction between Oxcarbazepine and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and switch to a non-inducing anticonvulsant such as levetiracetam before starting therapy.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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