Drug interactions
Oxcarbazepine + Theophylline
Severity: Moderate
Oxcarbazepine and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak to moderate enzyme inducer and may lower theophylline concentrations, though data on this pair are limited. Reduced bronchodilator control is possible.
What this interaction means in plain words
Oxcarbazepine and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Induction of hepatic cytochrome P450 enzymes increases theophylline clearance.
What to do
Monitor theophylline levels and clinical response when oxcarbazepine is started or stopped, and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Theophylline?
MediHelp rates the interaction as moderate. Oxcarbazepine and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak to moderate enzyme inducer and may lower theophylline concentrations, though data on this pair are limited. Reduced bronchodilator control is possible.
How serious is the interaction between Oxcarbazepine and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and clinical response when oxcarbazepine is started or stopped, and adjust the dose as needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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