Drug interactions
Oxcarbazepine + Ulipristal
Severity: Major
Oxcarbazepine and Ulipristal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is metabolized by CYP3A4, and inducers reduce its levels, which may make emergency contraception less effective. Oxcarbazepine is a recognized enzyme inducer that also reduces hormonal contraceptive effectiveness.
What this interaction means in plain words
Oxcarbazepine and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Oxcarbazepine induces CYP3A4, accelerating ulipristal metabolism.
What to do
Avoid ulipristal in patients taking oxcarbazepine; use a copper intrauterine device as emergency contraception instead.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Ulipristal?
MediHelp rates the interaction as major. Oxcarbazepine and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ulipristal is metabolized by CYP3A4, and inducers reduce its levels, which may make emergency contraception less effective. Oxcarbazepine is a recognized enzyme inducer that also reduces hormonal contraceptive effectiveness.
How serious is the interaction between Oxcarbazepine and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ulipristal in patients taking oxcarbazepine; use a copper intrauterine device as emergency contraception instead.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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