Drug interactions
Oxcarbazepine + Vorapaxar
Severity: Moderate
Oxcarbazepine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is cleared by CYP3A4, and strong inducers reduce its levels and antiplatelet effect. Oxcarbazepine is a weaker inducer, so the effect is likely smaller but could lessen thrombotic protection.
What this interaction means in plain words
Oxcarbazepine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Oxcarbazepine induces CYP3A4, increasing vorapaxar clearance.
What to do
Consider an alternative anticonvulsant and monitor for thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Vorapaxar?
MediHelp rates the interaction as moderate. Oxcarbazepine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is cleared by CYP3A4, and strong inducers reduce its levels and antiplatelet effect. Oxcarbazepine is a weaker inducer, so the effect is likely smaller but could lessen thrombotic protection.
How serious is the interaction between Oxcarbazepine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative anticonvulsant and monitor for thrombotic events.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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