Drug interactions
Oxcarbazepine + Zolpidem
Severity: Minor
Oxcarbazepine and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak inducer of CYP3A4 and may modestly lower zolpidem exposure. This could reduce hypnotic effect, though the change is usually small.
What this interaction means in plain words
Oxcarbazepine and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxcarbazepine belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by oxcarbazepine increases the hepatic metabolism of zolpidem.
What to do
No empirical dose change is needed; assess hypnotic response and adjust zolpidem within labeled limits if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Zolpidem?
MediHelp rates the interaction as minor. Oxcarbazepine and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine is a weak inducer of CYP3A4 and may modestly lower zolpidem exposure. This could reduce hypnotic effect, though the change is usually small.
How serious is the interaction between Oxcarbazepine and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; assess hypnotic response and adjust zolpidem within labeled limits if efficacy falls.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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