Drug interactions
Oxybutynin + Pimozide
Severity: Moderate
Oxybutynin and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide has anticholinergic effects, so combining with oxybutynin may increase dry mouth, constipation, urinary retention and confusion. Pimozide also prolongs the QT interval, and anticholinergic-related tachycardia adds to cardiac concerns.
What this interaction means in plain words
Oxybutynin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Pimozide belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity and heart rate or ECG as already required for pimozide. Choose a less anticholinergic option if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Oxybutynin with Pimozide?
MediHelp rates the interaction as moderate. Oxybutynin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide has anticholinergic effects, so combining with oxybutynin may increase dry mouth, constipation, urinary retention and confusion. Pimozide also prolongs the QT interval, and anticholinergic-related tachycardia adds to cardiac concerns.
How serious is the interaction between Oxybutynin and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and heart rate or ECG as already required for pimozide. Choose a less anticholinergic option if symptoms occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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