Drug interactions
Oxybutynin + Quinupristin / dalfopristin
Severity: Minor
Oxybutynin and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase oxybutynin concentrations. This could intensify anticholinergic adverse effects during the typically short antibiotic course.
What this interaction means in plain words
Oxybutynin and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated oxybutynin metabolism by quinupristin/dalfopristin.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation and confusion during co-administration; reduce the oxybutynin dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Frequently asked questions
Can I take Oxybutynin with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Oxybutynin and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and may increase oxybutynin concentrations. This could intensify anticholinergic adverse effects during the typically short antibiotic course.
How serious is the interaction between Oxybutynin and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation and confusion during co-administration; reduce the oxybutynin dose if they occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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