Drug interactions
Oxymetholone + Pioglitazone
Severity: Minor
Oxymetholone and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone, an anabolic androgenic steroid, may lower blood glucose and increase sensitivity to antidiabetic agents, which may add to the effect of pioglitazone. Both can cause fluid retention, and oxymetholone also carries hepatotoxicity risk.
What this interaction means in plain words
Oxymetholone and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucose-lowering effect through improved insulin sensitivity.
What to do
Monitor blood glucose and adjust pioglitazone dose if hypoglycemia occurs. Monitor liver tests and for edema during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Frequently asked questions
Can I take Oxymetholone with Pioglitazone?
MediHelp rates the interaction as minor. Oxymetholone and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymetholone, an anabolic androgenic steroid, may lower blood glucose and increase sensitivity to antidiabetic agents, which may add to the effect of pioglitazone. Both can cause fluid retention, and oxymetholone also carries hepatotoxicity risk.
How serious is the interaction between Oxymetholone and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust pioglitazone dose if hypoglycemia occurs. Monitor liver tests and for edema during combined use.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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