Drug interactions
Paclitaxel protein bound + Pazopanib
Severity: Moderate
Paclitaxel protein bound and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib may raise paclitaxel exposure, and this has been seen with conventional paclitaxel. Higher paclitaxel levels can worsen neutropenia, neuropathy and other dose-related toxicities.
What this interaction means in plain words
Paclitaxel protein bound and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pazopanib inhibits CYP2C8 and possibly other pathways, reducing paclitaxel metabolism.
What to do
Monitor blood counts and signs of neuropathy closely. Reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Paclitaxel protein bound with Pazopanib?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib may raise paclitaxel exposure, and this has been seen with conventional paclitaxel. Higher paclitaxel levels can worsen neutropenia, neuropathy and other dose-related toxicities.
How serious is the interaction between Paclitaxel protein bound and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy closely. Reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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