Drug interactions
Paclitaxel protein bound + Pioglitazone
Severity: Minor
Paclitaxel protein bound and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is a weak CYP2C8 inhibitor, and paclitaxel is a CYP2C8 substrate, so paclitaxel exposure could theoretically rise. Clinically significant effect is unlikely at usual doses.
What this interaction means in plain words
Paclitaxel protein bound and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2C8 inhibition by pioglitazone reduces paclitaxel metabolism.
What to do
No routine change; monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Frequently asked questions
Can I take Paclitaxel protein bound with Pioglitazone?
MediHelp rates the interaction as minor. Paclitaxel protein bound and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is a weak CYP2C8 inhibitor, and paclitaxel is a CYP2C8 substrate, so paclitaxel exposure could theoretically rise. Clinically significant effect is unlikely at usual doses.
How serious is the interaction between Paclitaxel protein bound and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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