Drug interactions
Paclitaxel protein bound + Quinine
Severity: Minor
Paclitaxel protein bound and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4. Quinine is not a recognized strong inhibitor of these enzymes, so a meaningful increase in paclitaxel exposure is unlikely and the evidence is minimal.
What this interaction means in plain words
Paclitaxel protein bound and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of paclitaxel metabolism; not well established.
What to do
No dose change is needed; monitor for neutropenia and neuropathy as per routine paclitaxel care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Quinine?
MediHelp rates the interaction as minor. Paclitaxel protein bound and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is metabolized by CYP2C8 and CYP3A4. Quinine is not a recognized strong inhibitor of these enzymes, so a meaningful increase in paclitaxel exposure is unlikely and the evidence is minimal.
How serious is the interaction between Paclitaxel protein bound and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for neutropenia and neuropathy as per routine paclitaxel care.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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