Drug interactions
Paclitaxel protein bound + Sacubitril-valsartan
Severity: Minor
Paclitaxel protein bound and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is transported into the liver by OATP1B1, and inhibitors of this transporter can theoretically increase valsartan exposure. Paclitaxel is not an established clinically important OATP1B1 inhibitor, so the interaction is largely theoretical.
What this interaction means in plain words
Paclitaxel protein bound and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical inhibition of OATP1B1-mediated hepatic uptake of valsartan; not well established for paclitaxel.
What to do
No empirical adjustment is needed; monitor blood pressure and renal function during chemotherapy, particularly with dehydration or vomiting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Paclitaxel protein bound and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is transported into the liver by OATP1B1, and inhibitors of this transporter can theoretically increase valsartan exposure. Paclitaxel is not an established clinically important OATP1B1 inhibitor, so the interaction is largely theoretical.
How serious is the interaction between Paclitaxel protein bound and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed; monitor blood pressure and renal function during chemotherapy, particularly with dehydration or vomiting.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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