Drug interactions
Paclitaxel protein bound + Tolvaptan
Severity: Minor
Paclitaxel protein bound and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein in vitro, and paclitaxel is a P-gp substrate, so paclitaxel exposure could theoretically rise. The clinical significance is uncertain.
What this interaction means in plain words
Paclitaxel protein bound and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of P-glycoprotein efflux of paclitaxel by tolvaptan.
What to do
No empirical dose change is needed. Monitor for increased myelosuppression and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Tolvaptan?
MediHelp rates the interaction as minor. Paclitaxel protein bound and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein in vitro, and paclitaxel is a P-gp substrate, so paclitaxel exposure could theoretically rise. The clinical significance is uncertain.
How serious is the interaction between Paclitaxel protein bound and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for increased myelosuppression and neuropathy.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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