Drug interactions
Paclitaxel protein bound + Trastuzumab
Severity: Moderate
Paclitaxel protein bound and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nab-paclitaxel frequently causes neutropenia. Combined with trastuzumab, neutropenia and febrile neutropenia may be more frequent, increasing infection risk.
What this interaction means in plain words
Paclitaxel protein bound and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression.
What to do
Monitor neutrophil counts before each cycle and for fever or infection. Delay or reduce nab-paclitaxel for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Paclitaxel protein bound with Trastuzumab?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nab-paclitaxel frequently causes neutropenia. Combined with trastuzumab, neutropenia and febrile neutropenia may be more frequent, increasing infection risk.
How serious is the interaction between Paclitaxel protein bound and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts before each cycle and for fever or infection. Delay or reduce nab-paclitaxel for significant neutropenia.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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