Drug interactions
Paclitaxel protein bound + Valsartan
Severity: Minor
Paclitaxel protein bound and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1, and inhibitors of this transporter might increase its exposure. Evidence that protein-bound paclitaxel produces a meaningful effect is weak and largely theoretical.
What this interaction means in plain words
Paclitaxel protein bound and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical inhibition of hepatic OATP1B1 uptake of valsartan.
What to do
No routine dose change is needed. Monitor blood pressure and renal function during chemotherapy, particularly if the patient becomes dehydrated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Paclitaxel protein bound with Valsartan?
MediHelp rates the interaction as minor. Paclitaxel protein bound and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1, and inhibitors of this transporter might increase its exposure. Evidence that protein-bound paclitaxel produces a meaningful effect is weak and largely theoretical.
How serious is the interaction between Paclitaxel protein bound and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and renal function during chemotherapy, particularly if the patient becomes dehydrated.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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