Drug interactions
Palifermin + Thioguanine
Severity: Moderate
Palifermin and Thioguanine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close in time to cytotoxic chemotherapy has been associated with more severe and longer oral mucositis, probably because it stimulates proliferation of epithelial cells that are then exposed to the cytotoxic drug. This negates its intended benefit.
What this interaction means in plain words
Palifermin and Thioguanine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Thioguanine belongs to Oncology.
Why it happens
Palifermin-driven epithelial cell proliferation increases sensitivity of mucosal cells to cytotoxic chemotherapy.
What to do
Do not give palifermin within 24 hours before, during, or after thioguanine. Follow the labeled schedule separating palifermin from chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Palifermin and Thioguanine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Thioguanine
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Thioguanine?
MediHelp rates the interaction as moderate. Palifermin and Thioguanine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close in time to cytotoxic chemotherapy has been associated with more severe and longer oral mucositis, probably because it stimulates proliferation of epithelial cells that are then exposed to the cytotoxic drug. This negates its intended benefit.
How serious is the interaction between Palifermin and Thioguanine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or after thioguanine. Follow the labeled schedule separating palifermin from chemotherapy.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
