Drug interactions
Palonosetron + Venlafaxine
Severity: Moderate
Palonosetron and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor, and 5-HT3 antagonists carry a labeled warning for serotonin syndrome when given with serotonergic drugs. Cases have been reported with this drug class, usually mild to moderate.
What this interaction means in plain words
Palonosetron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palonosetron belongs to Gastrointestinal Tract; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects; the contribution of 5-HT3 antagonists is not firmly established.
What to do
Monitor for serotonin syndrome, especially after starting or raising doses. Discontinue the agents and give supportive care if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Palonosetron with Venlafaxine?
MediHelp rates the interaction as moderate. Palonosetron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor, and 5-HT3 antagonists carry a labeled warning for serotonin syndrome when given with serotonergic drugs. Cases have been reported with this drug class, usually mild to moderate.
How serious is the interaction between Palonosetron and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, especially after starting or raising doses. Discontinue the agents and give supportive care if it occurs.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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