Drug interactions
Pantoprazole + Phenobarbital
Severity: Minor
Pantoprazole and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a broad enzyme inducer and may reduce pantoprazole concentrations, which could weaken acid suppression. Clinical impact is generally modest.
What this interaction means in plain words
Pantoprazole and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induces hepatic CYP enzymes (CYP2C19 and CYP3A4), accelerating pantoprazole clearance.
What to do
No routine change is needed; if symptoms of inadequate acid control occur, increase the pantoprazole dose or review therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Pantoprazole with Phenobarbital?
MediHelp rates the interaction as minor. Pantoprazole and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital is a broad enzyme inducer and may reduce pantoprazole concentrations, which could weaken acid suppression. Clinical impact is generally modest.
How serious is the interaction between Pantoprazole and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; if symptoms of inadequate acid control occur, increase the pantoprazole dose or review therapy.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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