Drug interactions
Pantoprazole + Rifampin
Severity: Moderate
Pantoprazole and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces hepatic drug-metabolizing enzymes, including CYP2C19, which lowers pantoprazole exposure. Acid suppression may be weaker as a result, especially in patients treated for acid-related disease.
What this interaction means in plain words
Pantoprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP2C19 (and CYP3A4), increasing the metabolic clearance of pantoprazole.
What to do
Monitor for loss of symptom control and consider increasing the pantoprazole dose if the response is inadequate. Reassess the dose after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Pantoprazole with Rifampin?
MediHelp rates the interaction as moderate. Pantoprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces hepatic drug-metabolizing enzymes, including CYP2C19, which lowers pantoprazole exposure. Acid suppression may be weaker as a result, especially in patients treated for acid-related disease.
How serious is the interaction between Pantoprazole and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider increasing the pantoprazole dose if the response is inadequate. Reassess the dose after rifampin is stopped.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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