Drug interactions
Paracetamol + Volanesorsen
Severity: Moderate
Paracetamol and Volanesorsen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volanesorsen can cause liver enzyme elevations, and paracetamol is a recognised hepatotoxin at high doses. Using them together could theoretically add to liver injury risk, although no formal interaction data exist.
What this interaction means in plain words
Paracetamol and Volanesorsen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paracetamol belongs to Musculoskeletal; Volanesorsen belongs to Cardiovascular.
Why it happens
Possible additive hepatotoxicity; no established pharmacokinetic interaction.
What to do
Keep paracetamol at the lowest effective dose and avoid chronic high-dose use. Monitor liver function and stop the suspected hepatotoxic agent if liver injury signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Frequently asked questions
Can I take Paracetamol with Volanesorsen?
MediHelp rates the interaction as moderate. Paracetamol and Volanesorsen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volanesorsen can cause liver enzyme elevations, and paracetamol is a recognised hepatotoxin at high doses. Using them together could theoretically add to liver injury risk, although no formal interaction data exist.
How serious is the interaction between Paracetamol and Volanesorsen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep paracetamol at the lowest effective dose and avoid chronic high-dose use. Monitor liver function and stop the suspected hepatotoxic agent if liver injury signs appear.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
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