Drug interactions
Parecoxib + Prednisolone
Severity: Moderate
Parecoxib and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID such as parecoxib raises the risk of gastrointestinal ulceration and bleeding. Selective COX-2 inhibitors carry somewhat less GI risk than non-selective NSAIDs but the risk is not eliminated.
What this interaction means in plain words
Parecoxib and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition and corticosteroid effects impair mucosal defense and healing, giving additive GI toxicity.
What to do
Use the shortest course possible and consider a proton pump inhibitor in high-risk patients. Counsel patients to report GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Parecoxib with Prednisolone?
MediHelp rates the interaction as moderate. Parecoxib and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID such as parecoxib raises the risk of gastrointestinal ulceration and bleeding. Selective COX-2 inhibitors carry somewhat less GI risk than non-selective NSAIDs but the risk is not eliminated.
How serious is the interaction between Parecoxib and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest course possible and consider a proton pump inhibitor in high-risk patients. Counsel patients to report GI bleeding symptoms.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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