Drug interactions
Parecoxib + Terazosin
Severity: Moderate
Parecoxib and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, converted to valdecoxib, is a COX-2 inhibitor that may raise blood pressure and reduce antihypertensive efficacy. The risk is greater with prolonged use or renal impairment.
What this interaction means in plain words
Parecoxib and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandins, causing sodium and water retention and opposing vasodilation.
What to do
Monitor blood pressure during parecoxib therapy and keep the course as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Parecoxib with Terazosin?
MediHelp rates the interaction as moderate. Parecoxib and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, converted to valdecoxib, is a COX-2 inhibitor that may raise blood pressure and reduce antihypertensive efficacy. The risk is greater with prolonged use or renal impairment.
How serious is the interaction between Parecoxib and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during parecoxib therapy and keep the course as short as possible.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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