Drug interactions
Parecoxib + Timolol
Severity: Moderate
Parecoxib and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib, particularly with sustained use, can blunt the blood pressure lowering effect of beta-blockers by reducing vasodilatory prostaglandins and promoting sodium and fluid retention. Parecoxib may also impair renal function, which adds to the concern in patients with cardiovascular disease.
What this interaction means in plain words
Parecoxib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and water retention and antagonizes the antihypertensive effect of the beta-blocker.
What to do
Monitor blood pressure and renal function if the combination continues beyond a short course, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Parecoxib with Timolol?
MediHelp rates the interaction as moderate. Parecoxib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib, particularly with sustained use, can blunt the blood pressure lowering effect of beta-blockers by reducing vasodilatory prostaglandins and promoting sodium and fluid retention. Parecoxib may also impair renal function, which adds to the concern in patients with cardiovascular disease.
How serious is the interaction between Parecoxib and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if the combination continues beyond a short course, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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