Drug interactions
Parecoxib + Trandolapril
Severity: Moderate
Parecoxib and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to the COX-2 inhibitor valdecoxib and can reduce the antihypertensive effect of trandolapril. In dehydrated, elderly or renally impaired patients the combination may cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Parecoxib and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandin synthesis, opposing ACE inhibitor effects and lowering renal perfusion.
What to do
Monitor blood pressure, renal function and potassium, maintain hydration, and limit parecoxib to the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Parecoxib with Trandolapril?
MediHelp rates the interaction as moderate. Parecoxib and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to the COX-2 inhibitor valdecoxib and can reduce the antihypertensive effect of trandolapril. In dehydrated, elderly or renally impaired patients the combination may cause acute kidney injury and hyperkalemia.
How serious is the interaction between Parecoxib and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, maintain hydration, and limit parecoxib to the shortest duration.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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