Drug interactions
Paroxetine + Promazine
Severity: Moderate
Paroxetine and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine inhibits CYP2D6 and may increase promazine exposure. Both drugs can prolong the QT interval, and phenothiazines plus SSRIs also add serotonergic and sedative effects, so risk of arrhythmia and adverse effects rises.
What this interaction means in plain words
Paroxetine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by paroxetine plus additive QT prolongation.
What to do
Monitor ECG and electrolytes, especially with other QT-prolonging risks. Lower the promazine dose if sedation, hypotension or extrapyramidal effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Promazine?
MediHelp rates the interaction as moderate. Paroxetine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine inhibits CYP2D6 and may increase promazine exposure. Both drugs can prolong the QT interval, and phenothiazines plus SSRIs also add serotonergic and sedative effects, so risk of arrhythmia and adverse effects rises.
How serious is the interaction between Paroxetine and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, especially with other QT-prolonging risks. Lower the promazine dose if sedation, hypotension or extrapyramidal effects appear.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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