Drug interactions
Paroxetine + Remimazolam
Severity: Moderate
Paroxetine and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine sedative, and other CNS depressants can deepen sedation and respiratory depression. Paroxetine has mild sedative properties, so the added effect is usually modest but should be anticipated.
What this interaction means in plain words
Paroxetine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and sedative effects of paroxetine.
What to do
Titrate remimazolam carefully and monitor oxygen saturation, respiratory rate and blood pressure throughout sedation and recovery. Use only in settings with resuscitation capability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Paroxetine with Remimazolam?
MediHelp rates the interaction as moderate. Paroxetine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a short-acting benzodiazepine sedative, and other CNS depressants can deepen sedation and respiratory depression. Paroxetine has mild sedative properties, so the added effect is usually modest but should be anticipated.
How serious is the interaction between Paroxetine and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and monitor oxygen saturation, respiratory rate and blood pressure throughout sedation and recovery. Use only in settings with resuscitation capability.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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