Drug interactions
Paroxetine + Salsalate
Severity: Moderate
Paroxetine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with weaker platelet effects, but NSAID-type GI toxicity still applies. With an SSRI, bleeding risk is somewhat increased.
What this interaction means in plain words
Paroxetine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
SSRI-induced platelet dysfunction added to NSAID-related gastrointestinal mucosal injury.
What to do
Use the lowest effective salsalate dose and consider gastroprotection in at-risk patients. Monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Salsalate?
MediHelp rates the interaction as moderate. Paroxetine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate with weaker platelet effects, but NSAID-type GI toxicity still applies. With an SSRI, bleeding risk is somewhat increased.
How serious is the interaction between Paroxetine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salsalate dose and consider gastroprotection in at-risk patients. Monitor for GI bleeding.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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