Drug interactions
Paroxetine + Selegiline transdermal
Severity: Contraindicated
Paroxetine and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and combining it with an SSRI like paroxetine may cause serotonin syndrome or hypertensive reactions. The transdermal antidepressant labeling contraindicates use with SSRIs.
What this interaction means in plain words
Paroxetine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition by selegiline combined with serotonin reuptake inhibition by paroxetine.
What to do
Do not combine. Allow at least 2 weeks after stopping selegiline before starting paroxetine, and at least 2 weeks after stopping paroxetine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Paroxetine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO inhibitor, and combining it with an SSRI like paroxetine may cause serotonin syndrome or hypertensive reactions. The transdermal antidepressant labeling contraindicates use with SSRIs.
How serious is the interaction between Paroxetine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow at least 2 weeks after stopping selegiline before starting paroxetine, and at least 2 weeks after stopping paroxetine before starting selegiline.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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