Drug interactions
Paroxetine + Sufentanil sl
Severity: Moderate
Paroxetine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids like sufentanil have serotonergic activity in some cases and, with SSRIs, may rarely cause serotonin syndrome. Paroxetine also inhibits CYP2D6 but sufentanil is mainly CYP3A4 cleared, so the main concern is pharmacodynamic. CNS depression may also add.
What this interaction means in plain words
Paroxetine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects and additive CNS depression.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and excess sedation, particularly at initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Sufentanil sl?
MediHelp rates the interaction as moderate. Paroxetine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids like sufentanil have serotonergic activity in some cases and, with SSRIs, may rarely cause serotonin syndrome. Paroxetine also inhibits CYP2D6 but sufentanil is mainly CYP3A4 cleared, so the main concern is pharmacodynamic. CNS depression may also add.
How serious is the interaction between Paroxetine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and excess sedation, particularly at initiation and dose changes.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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