Drug interactions
Paroxetine + Sulfamethoxazole
Severity: Minor
Paroxetine and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, though paroxetine's effect is small and sulfamethoxazole's is uncertain. Clinically significant interaction is unlikely in most patients but may matter with other risk factors.
What this interaction means in plain words
Paroxetine and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive QT prolongation; mechanism poorly established.
What to do
No routine action; check ECG and electrolytes if the patient has other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Sulfamethoxazole?
MediHelp rates the interaction as minor. Paroxetine and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been associated with QT prolongation, though paroxetine's effect is small and sulfamethoxazole's is uncertain. Clinically significant interaction is unlikely in most patients but may matter with other risk factors.
How serious is the interaction between Paroxetine and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; check ECG and electrolytes if the patient has other QT risk factors.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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