Drug interactions
Paroxetine + Thiothixene
Severity: Moderate
Paroxetine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an antipsychotic such as thiothixene can add serotonergic and dopamine-blocking effects. This may rarely cause serotonin syndrome or neuroleptic malignant syndrome, and paroxetine may increase antipsychotic levels via CYP2D6.
What this interaction means in plain words
Paroxetine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopamine antagonist effects with possible CYP2D6 inhibition.
What to do
Monitor for mental status change, fever, rigidity, autonomic instability and extrapyramidal symptoms. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Thiothixene?
MediHelp rates the interaction as moderate. Paroxetine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an antipsychotic such as thiothixene can add serotonergic and dopamine-blocking effects. This may rarely cause serotonin syndrome or neuroleptic malignant syndrome, and paroxetine may increase antipsychotic levels via CYP2D6.
How serious is the interaction between Paroxetine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, fever, rigidity, autonomic instability and extrapyramidal symptoms. Use the lowest effective doses.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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