Drug interactions
Passion flower + Promethazine
Severity: Minor
Passion flower and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has sedative and anxiolytic properties and may add to the drowsiness caused by promethazine. Impaired alertness and psychomotor performance may result.
What this interaction means in plain words
Passion flower and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression, possibly via GABAergic activity of passion flower constituents.
What to do
Advise patients to avoid driving or hazardous tasks until response is known. Stop the herbal product if oversedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Passion flower and Promethazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Passion flower with Promethazine?
MediHelp rates the interaction as minor. Passion flower and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Passion flower has sedative and anxiolytic properties and may add to the drowsiness caused by promethazine. Impaired alertness and psychomotor performance may result.
How serious is the interaction between Passion flower and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks until response is known. Stop the herbal product if oversedation occurs.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
