Drug interactions
Pazopanib + Pentobarbital
Severity: Moderate
Pazopanib and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital may lower pazopanib concentrations and reduce its antitumor efficacy. The effect is likely to be significant with prolonged use.
What this interaction means in plain words
Pazopanib and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pentobarbital induces CYP3A4, increasing the metabolism of pazopanib.
What to do
Use a non-inducing sedative or hypnotic if possible. If the combination is needed, monitor tumor response and consider the loss of pazopanib effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pazopanib and Pentobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Pentobarbital?
MediHelp rates the interaction as moderate. Pazopanib and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital may lower pazopanib concentrations and reduce its antitumor efficacy. The effect is likely to be significant with prolonged use.
How serious is the interaction between Pazopanib and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing sedative or hypnotic if possible. If the combination is needed, monitor tumor response and consider the loss of pazopanib effect.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
