Drug interactions
Pazopanib + Pitavastatin
Severity: Moderate
Pazopanib and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can inhibit the hepatic uptake transporter OATP1B1, which pitavastatin depends on to enter hepatocytes. Higher circulating pitavastatin levels may follow, raising the chance of muscle toxicity. The size of the effect in practice is uncertain.
What this interaction means in plain words
Pazopanib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Pitavastatin belongs to Cardiovascular.
Why it happens
Pazopanib inhibits OATP1B1-mediated hepatic uptake of pitavastatin, increasing systemic statin exposure.
What to do
Use the lowest effective pitavastatin dose and ask the patient to report unexplained muscle pain or weakness. Check creatine kinase if symptoms occur and stop the statin if myopathy is confirmed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Pitavastatin?
MediHelp rates the interaction as moderate. Pazopanib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib can inhibit the hepatic uptake transporter OATP1B1, which pitavastatin depends on to enter hepatocytes. Higher circulating pitavastatin levels may follow, raising the chance of muscle toxicity. The size of the effect in practice is uncertain.
How serious is the interaction between Pazopanib and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and ask the patient to report unexplained muscle pain or weakness. Check creatine kinase if symptoms occur and stop the statin if myopathy is confirmed.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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