Drug interactions
Pazopanib + Ponatinib
Severity: Moderate
Pazopanib and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may increase pazopanib exposure by inhibiting its efflux. This could heighten pazopanib adverse effects such as hepatotoxicity, hypertension and diarrhea.
What this interaction means in plain words
Pazopanib and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits P-glycoprotein and probably BCRP, reducing efflux of pazopanib.
What to do
Monitor liver enzymes and blood pressure. Reduce the pazopanib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Pazopanib with Ponatinib?
MediHelp rates the interaction as moderate. Pazopanib and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib may increase pazopanib exposure by inhibiting its efflux. This could heighten pazopanib adverse effects such as hepatotoxicity, hypertension and diarrhea.
How serious is the interaction between Pazopanib and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood pressure. Reduce the pazopanib dose if toxicity occurs.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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