Drug interactions
Pazopanib + Rifampin
Severity: Major
Pazopanib and Rifampin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4 and can substantially lower pazopanib exposure. Reduced concentrations may lead to loss of antitumor efficacy.
What this interaction means in plain words
Pazopanib and Rifampin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Rifampin induces CYP3A4 (and possibly P-gp), increasing pazopanib metabolism and clearance.
What to do
Avoid combination and choose a non-inducing alternative where possible. If unavoidable, monitor tumor response closely, as pazopanib dose increases are generally not recommended.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Rifampin?
MediHelp rates the interaction as major. Pazopanib and Rifampin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampin strongly induces CYP3A4 and can substantially lower pazopanib exposure. Reduced concentrations may lead to loss of antitumor efficacy.
How serious is the interaction between Pazopanib and Rifampin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and choose a non-inducing alternative where possible. If unavoidable, monitor tumor response closely, as pazopanib dose increases are generally not recommended.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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