Drug interactions
Pazopanib + Romidepsin
Severity: Moderate
Pazopanib and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause ECG changes. Together they increase the risk of arrhythmia.
What this interaction means in plain words
Pazopanib and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline ECG, potassium and magnesium, and monitor during therapy. Correct electrolyte deficits before each romidepsin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Romidepsin?
MediHelp rates the interaction as moderate. Pazopanib and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause ECG changes. Together they increase the risk of arrhythmia.
How serious is the interaction between Pazopanib and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium and magnesium, and monitor during therapy. Correct electrolyte deficits before each romidepsin dose.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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