Drug interactions
Pazopanib + Sacubitril / valsartan
Severity: Minor
Pazopanib and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 and may raise valsartan exposure. This could increase hypotension, hyperkalemia or renal effects.
What this interaction means in plain words
Pazopanib and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pazopanib inhibits OATP1B1-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure, potassium and renal function. Adjust the sacubitril/valsartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Pazopanib and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib inhibits OATP1B1 and may raise valsartan exposure. This could increase hypotension, hyperkalemia or renal effects.
How serious is the interaction between Pazopanib and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function. Adjust the sacubitril/valsartan dose if hypotension occurs.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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