Drug interactions
Pazopanib + Sulbactam / durlobactam
Severity: Minor
Pazopanib and Sulbactam / durlobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib may inhibit renal organic anion transporters and raise sulbactam exposure. This is largely a theoretical concern, and sulbactam has a wide safety margin.
What this interaction means in plain words
Pazopanib and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OAT-mediated renal tubular secretion of sulbactam by pazopanib.
What to do
No dose adjustment is generally needed. Monitor for beta-lactam adverse effects such as rash, diarrhea or neurotoxicity in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Sulbactam / durlobactam?
MediHelp rates the interaction as minor. Pazopanib and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib may inhibit renal organic anion transporters and raise sulbactam exposure. This is largely a theoretical concern, and sulbactam has a wide safety margin.
How serious is the interaction between Pazopanib and Sulbactam / durlobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for beta-lactam adverse effects such as rash, diarrhea or neurotoxicity in renal impairment.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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