Drug interactions
Pazopanib + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Pazopanib and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib prolongs QTc and vilanterol may add cardiovascular stimulation and QT effects. Systemic exposure after inhalation is low, so the risk is modest but higher in patients with cardiac disease.
What this interaction means in plain words
Pazopanib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiac effects.
What to do
Monitor ECG and potassium in patients with cardiac risk factors. Do not exceed the labeled inhaler dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Pazopanib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib prolongs QTc and vilanterol may add cardiovascular stimulation and QT effects. Systemic exposure after inhalation is low, so the risk is modest but higher in patients with cardiac disease.
How serious is the interaction between Pazopanib and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with cardiac risk factors. Do not exceed the labeled inhaler dose.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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