Drug interactions
Peginterferon alfa 2a + Rasagiline
Severity: Moderate
Peginterferon alfa 2a and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2a may reduce CYP1A2-mediated metabolism of rasagiline and increase its exposure. This could heighten dopaminergic and MAO-B inhibitor adverse effects.
What this interaction means in plain words
Peginterferon alfa 2a and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Peginterferon alfa 2a belongs to Anti Virals; Rasagiline belongs to Central Nervous System.
Why it happens
Interferon-related inhibition of CYP1A2 decreases rasagiline clearance.
What to do
Limit rasagiline to 0.5 mg daily during concomitant use, as labeling advises for CYP1A2 inhibitors. Monitor for adverse effects such as dyskinesia and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Peginterferon alfa 2a and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Peginterferon alfa 2a
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Peginterferon alfa 2a with Rasagiline?
MediHelp rates the interaction as moderate. Peginterferon alfa 2a and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa 2a may reduce CYP1A2-mediated metabolism of rasagiline and increase its exposure. This could heighten dopaminergic and MAO-B inhibitor adverse effects.
How serious is the interaction between Peginterferon alfa 2a and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rasagiline to 0.5 mg daily during concomitant use, as labeling advises for CYP1A2 inhibitors. Monitor for adverse effects such as dyskinesia and hypotension.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxyurea. The full list is on the Peginterferon alfa 2a page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
