Drug interactions
Peginterferon alfa 2a + Ropinirole
Severity: Moderate
Peginterferon alfa 2a and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2a may reduce CYP1A2 metabolism of ropinirole, raising its plasma levels. This may increase somnolence, nausea, dizziness and hypotension.
What this interaction means in plain words
Peginterferon alfa 2a and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Peginterferon alfa 2a belongs to Anti Virals; Ropinirole belongs to Central Nervous System.
Why it happens
Interferon-mediated suppression of CYP1A2 lowers ropinirole clearance.
What to do
Monitor for dopaminergic adverse effects and sedation when the interferon is started. Reduce the ropinirole dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Peginterferon alfa 2a
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Peginterferon alfa 2a with Ropinirole?
MediHelp rates the interaction as moderate. Peginterferon alfa 2a and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa 2a may reduce CYP1A2 metabolism of ropinirole, raising its plasma levels. This may increase somnolence, nausea, dizziness and hypotension.
How serious is the interaction between Peginterferon alfa 2a and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects and sedation when the interferon is started. Reduce the ropinirole dose if needed.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxyurea. The full list is on the Peginterferon alfa 2a page.
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