Drug interactions
Penbutolol + Sacubitril-valsartan
Severity: Minor
Penbutolol and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure and heart rate effects may add together, which can cause hypotension or bradycardia. Beta-blockers can also slightly impair potassium uptake into cells, modestly raising potassium. Combination is common in heart failure and generally well tolerated.
What this interaction means in plain words
Penbutolol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic blood pressure lowering; beta-blockade can reduce cellular potassium uptake.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or titrating either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Penbutolol with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Penbutolol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents lower blood pressure and heart rate effects may add together, which can cause hypotension or bradycardia. Beta-blockers can also slightly impair potassium uptake into cells, modestly raising potassium. Combination is common in heart failure and generally well tolerated.
How serious is the interaction between Penbutolol and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or titrating either drug.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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