Drug interactions
Penbutolol + Tadalafil
Severity: Moderate
Penbutolol and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has mild vasodilatory effects that can add to the blood pressure lowering of beta-blockers. Symptomatic hypotension is possible but is usually modest.
What this interaction means in plain words
Penbutolol and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering from PDE5-mediated vasodilation and beta-adrenergic blockade.
What to do
Monitor blood pressure and symptoms of orthostasis after starting tadalafil. Begin with a low dose in patients on stable beta-blocker therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Penbutolol with Tadalafil?
MediHelp rates the interaction as moderate. Penbutolol and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has mild vasodilatory effects that can add to the blood pressure lowering of beta-blockers. Symptomatic hypotension is possible but is usually modest.
How serious is the interaction between Penbutolol and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of orthostasis after starting tadalafil. Begin with a low dose in patients on stable beta-blocker therapy.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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