Drug interactions
Penbutolol + Tolmetin
Severity: Moderate
Penbutolol and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers, particularly with continued use over more than a week. Blood pressure may rise and control may be lost.
What this interaction means in plain words
Penbutolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit vasodilatory renal and vascular prostaglandin synthesis and promote sodium and fluid retention, opposing the blood pressure lowering of beta-blockers.
What to do
Monitor blood pressure when tolmetin is started or continued for more than a few days, and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Penbutolol with Tolmetin?
MediHelp rates the interaction as moderate. Penbutolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of beta-blockers, particularly with continued use over more than a week. Blood pressure may rise and control may be lost.
How serious is the interaction between Penbutolol and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when tolmetin is started or continued for more than a few days, and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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