Drug interactions
Penicillamine + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Penicillamine and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This bowel preparation forms magnesium citrate in the gut, and magnesium cations can bind penicillamine and reduce its absorption. Bowel cleansing also speeds transit, further limiting absorption.
What this interaction means in plain words
Penicillamine and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation by magnesium and accelerated gastrointestinal transit reduce penicillamine absorption.
What to do
Take penicillamine at least 2 hours before and not sooner than 6 hours after the bowel preparation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Penicillamine with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Penicillamine and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This bowel preparation forms magnesium citrate in the gut, and magnesium cations can bind penicillamine and reduce its absorption. Bowel cleansing also speeds transit, further limiting absorption.
How serious is the interaction between Penicillamine and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take penicillamine at least 2 hours before and not sooner than 6 hours after the bowel preparation.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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