Drug interactions
Penicillamine + Tenofovir df
Severity: Moderate
Penicillamine and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can injure the kidney, and impaired renal function may raise tenofovir exposure. Combined use may increase the risk of nephrotoxicity.
What this interaction means in plain words
Penicillamine and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of tenofovir as kidney function declines.
What to do
Monitor serum creatinine, phosphate and urinary protein, and adjust tenofovir dosing for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Penicillamine with Tenofovir df?
MediHelp rates the interaction as moderate. Penicillamine and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can injure the kidney, and impaired renal function may raise tenofovir exposure. Combined use may increase the risk of nephrotoxicity.
How serious is the interaction between Penicillamine and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinary protein, and adjust tenofovir dosing for renal function.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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