Drug interactions
Penicillamine + Tenofovir disoproxil
Severity: Moderate
Penicillamine and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillamine can cause proteinuria and nephrotic syndrome through immune-mediated glomerular injury, and tenofovir can cause tubular toxicity. Together they may add to renal injury, which can raise tenofovir exposure further.
What this interaction means in plain words
Penicillamine and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity by different renal mechanisms.
What to do
Monitor urinalysis for protein, serum creatinine and phosphate regularly. Stop or replace the offending agent if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Penicillamine with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Penicillamine and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillamine can cause proteinuria and nephrotic syndrome through immune-mediated glomerular injury, and tenofovir can cause tubular toxicity. Together they may add to renal injury, which can raise tenofovir exposure further.
How serious is the interaction between Penicillamine and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinalysis for protein, serum creatinine and phosphate regularly. Stop or replace the offending agent if renal function worsens.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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