Drug interactions
Pentobarbital + Pimavanserin
Severity: Moderate
Pentobarbital and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may lower pimavanserin exposure, reducing its effect. Both also act on the central nervous system, so sedation may be additive.
What this interaction means in plain words
Pentobarbital and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases pimavanserin clearance.
What to do
Monitor for diminished antipsychotic effect and consider a pimavanserin dose increase if the combination is continued. Watch for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Pentobarbital with Pimavanserin?
MediHelp rates the interaction as moderate. Pentobarbital and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may lower pimavanserin exposure, reducing its effect. Both also act on the central nervous system, so sedation may be additive.
How serious is the interaction between Pentobarbital and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished antipsychotic effect and consider a pimavanserin dose increase if the combination is continued. Watch for excess sedation.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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